Testosterone Replacement Therapy Side Effects

Testosterone replacement therapy side effects

Are you considering Testosterone Replacement Therapy in order to feel younger and more vigorous in bed? If yes, then you should know the possible risks and side effects that you can suffer from before making any decision.

Testosterone surely needs no introduction if you are a man. But to refresh your knowledge, it is the sexual hormone of prime importance that is responsible for the development of sexual and reproductive organs in men along with several other functions. But this hormone drops in males as they age thereby, decreasing the libido production and their desire to engage in sex. In this context, there introduced a therapy termed as Testosterone Replacement Therapy that is carried out to boost the Testosterone level in the person.

Testosterone Replacement Therapy – An Increasingly Popular Term:

Though, Testosterone Replacement Therapy has been around for a while, but this term is now going viral and is becoming more and more familiar by the people. The term, “Testosterone Replacement Therapy” has rapidly become very popular among the people because of the increased knowledge of Low Testosterone levels among the people.

As a matter of fact, people with the low testosterone levels are directly engaging in this therapy that is not very well- appreciated by the researchers. But it has surely helped the millions of men to get benefited from. This therapy is used by the men in order to regain their youthfulness, sex drive, libido and the golden years.

There are the numbers of techniques through which the Testosterone Replacement Therapy is conducted but it is not considered to be the safest therapy to use.

What actually Testosterone Replacement Therapy is?

Now, if you are wondering that what exactly the Testosterone Replacement Therapy is, then your research should end here. I am going to explain the whole process of Testosterone Replacement Therapy further in the article.

Testosterone Replacement Therapy or TRT is actually the variant of the Hormone Replacement Therapy that deals specifically with the Testosterone hormones that needs to be treated in order to increase its level in the body. The therapy is conducted actually by applying the Testosterone in the individual’s blood stream that can elevate the T levels in the person.

Who can Take Testosterone Replacement Therapy?

Now this question can arise in your mind that who are the persons that are eligible to take the Testosterone Replacement Therapy? Among the candidates for the therapy, the people who are considered to be deficient in Testosterone contents can pursue this therapy. According to the studies conducted on the Testosterone by Mayo Clinic, it is suggested that people having Testosterone levels below than normal range that is 300 – 700 ng/dL are considered to be deficient in Testosterone.

Moreover, the older persons that have declined testosterone levels are also eligible to take the Testosterone Replacement Therapy.

Methods of Testosterone Replacement Therapy:

As with the emerging popularity among the people, the Testosterone Replacement Therapy has been evolving in its forms. There are a number of options that are available for the Testosterone Replacement Therapy. The methods of Testosterone Replacement Therapy include:

  1. Oral Therapy:

Among the oral Testosterone Replacement Therapy, pills and dissolving strips are the most common treatments of boosting T levels. But this treatment is often discouraged because of the fact that it is ineffective and instead of increasing the T levels, it causes the complication of liver.

  1. Topical Application:

Topical application of the gels and Ointments are the methods that are included in the topical application route. This is the method in which gels and patches are applied to the body parts. This technique is considered to be effective one as the gels are absorbed in the body effectively and it does not affect the serum lipids of the body.

  1. Injections:

The most cost- effective and the best way of the Testosterone Replacement Therapy are the injections that are administrated in the subject’s body depending upon his condition. It is most effective method as the Testosterone hormone gets absorbed directly into the blood stream of a person.

As these methods of the Testosterone Replacement Therapy are beneficial to the person, they are equally harmful to the person as well. Here are the side effects that can be the result of the Testosterone Replacement Therapy.

The Side Effects of the Testosterone Replacement Therapy:

The risks and the side effects of the Testosterone Replacement Therapy depend on the number of factors. Among these factors, the most important ones are age, life circumstances and the medical conditions of the person. However, the observed side effects of the TRT among the men are as follows:

  1. Elevated DHT and Estradiol:

DHT and Estradiol are the two primary metabolites of the testosterone that results as the metabolism of this hormone. With the TRT, the levels of these metabolites in the human body are suggested to increase that can cause a number of serious problems in men. As a matter of fact, the elevated levels of DHT can cause:

  • the benign growth of prostate
  • Increased oiliness of the skin
  • Acne
  • Male pattern balding

Whereas the abnormal increase in the estradiol can lead to:

  • Mood swings
  • Breast tissue changes
  • Fluid retention in body causing swelling
  • Increase in blood pressure

However, according to the study conducted by An Endocrine Society Clinical Practice Guideline, it was suggested that these ratios may negatively affect the person only when treated with gels, pallets and patches. The therapy conducted via injections does not affect the person in such a negative way.

  1. Prostate Changes:

It is often thought that Prostate cancer can be a result of the Testosterone Replacement Therapy as prostate changes can occur with the TRT. But according to the study published in The Journal of Clinical Endocrinology & Metabolism, it was suggested that with the TRT there are no increased risk of the development of prostate cancer. But for the men with the personal prostate cancer history, the treatment for the low T levels can definitely cause the liaisions over prostate and that can aggressively grow if left untreated.

  1. Suppression of Fertility:

TRT is not recommended for the men who are interested in becoming fathers. A number of studies revealed that the TRT is taken by the persons having low Testosterone levels, the brain reduces the stimulus the natural hormones that are necessary for the fertility. The natural suppression of these hormones can reduce the fertility that is often characterized by the firmness of the testes.

  1. Sleep Apnea:

Sleep Apnea is the disorder of the sleep that is seriously characterized by the repeated disruption in breathing due to the loss of oxygen supply. This comes with no surprise that the testosterone levels highly influence the sleeping cycle of the man and so the therapy of the Testosterone Replacement can increase the odds of getting this disease. And according to the number of studies, if you are already suffering from Sleep Apnea, then TRT can worsen the symptoms.

  1. Increased Levels of Red Blood Cells:

Beyond the number of red blood cells that are healthy for your body, the Testosterone Replacement Therapy can increase their number too. This is another common side effect of the TRT that promotes the synthesis of red blood cells on the excess basis. As red blood cells can influence the viscosity of the blood, the increased count of these cells in the blood can lead to the thicker blood that can increase chances of forming blood clots and subsequently, the chances of heart attack and heart failure follow.


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